10 Best Supplements for Leaky Gut in 2021 & Beyond

best supplements for leaky gut

Read thoroughly for finding out your best supplements for leaky gut!

Leaky gut is a layman term for intestinal permeability. The name may sound funny for some of us. But it is a severe health condition that brings lifelong suffering to many people around the globe. The worst part of this syndrome is that it is not entirely cured through any medicine or surgery.

Experts suggest treating and managing leaky gut using the best supplements for leaky gut readily available in the market. There are different types of supplements for various conditions of leaky gut. Keep reading this personal experience-based article to learn more about this syndrome and leaky gut supplements reviews.

The dilemma in treating this syndrome is that many medical professionals do not consider it an actual medical condition. Likewise, there are no accurate statistics to know how many people around the world suffer from it.

As doctors began to record rising complaints of medical conditions, they have started to collect data. Above all, they are looking for its treatment. To date, doctors only refer for its symptomatic management, and no treatment is yet available.

With the advancements in medical sciences and pharmacology, you may think I am just creating hype. Still, you can refer to any authentic medical information library or a doctor for verification. In such a situation, the doctors only try to manage the symptoms to decrease the severity of the disease.

Leaky Gut Syndrome- All You Need To Know:

Some people are not clear about what leaky gut syndrome is. Many people suffer from frequent digestive problems of bloating, gas, acidity, or diarrhea that happen repeatedly. This condition is alarming, but it is not a leaky gut syndrome representing a complicated situation that affects the intestine. Certainly, this organ plays a crucial role in the digestive system.

The intestine is located after the stomach. All the breakdown of food occurs in the mouth and stomach, and its absorption takes place in the intestine. The intestine walls are thinner than the rest of the organs; they are only one cell thick, which means single cells are placed side by side. However, the structure supports the function of the intestine. Nutrients from the digested food pass the cell barrier line and go into the bloodstream.

In leaky gut syndrome, the permeability of the intestine increases as the gap between the cells in intestinal walls increases. Therefore, it allows bacteria, bacterial toxins, and other toxic materials to pass through and enter the bloodstream. With blood, these harmful agents can spread in the body and cause illness.

It is known as a syndrome because it represents signs and symptoms of the condition. The leading cause of increased intestinal permeability is diet. Several diseases are enlisted in this syndrome. The diseases include:

  • Food allergies
  • Crohn’s disease
  • Inflammatory bowel disease
  • Celiac disease
  • Diabetes type 1
  • Chronic liver disease
  • Polycystic ovarian syndrome

The chance of occurrence of these diseases increases in the presence of several risk factors.

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The causes and risk factors include:

  • Poor nutrition
  • Infections
  • Diabetes
  • Stress
  • Autoimmune disorders
  • Alcohol consumption
  • Yeast overgrowth

All these diseases are represented through some common signs and symptoms. The common ones include:

  • Weakness
  • Fatigue
  • Stomach cramps
  • Chronic bloating, diarrhea, and constipation
  • Joint pain
  • Confusion

Along with these common signs and symptoms, we are presenting some specific signs and symptoms. They will help the doctors from the basis they suspect leaky gut syndrome or you can diagnose it at home.

Signs and symptoms include:

  • Mood swings and neurological problems
  • Digestive problems
  • Food-related problems
  • Skin problems
  • Nutritional deficiencies

Leaky gut syndrome can cause severe effects on health. So, one should always look forward to getting proper treatment. As mentioned earlier, good guidelines on treatment are present now, but this does not mean leaving it untreated. The first line of therapy described by health care practitioners includes lifestyle changes and dietary changes. It is the first approach to improve gut health.

The lifestyle changes include:

  • Reducing stress
  • Exercising regularly
  • Quitting smoking
  • Avoiding unnecessary medication, such as antibiotics and painkillers
  • Getting goodnight sleep

The dietary changes include:

  • Enhancing intake of probiotics
  • Taking the diet which is rich in probiotic fiber
  • Eating an appropriate amount of eggs, meat, and dairy
  • Avoiding preserved well
  • Reducing the amount of sugar and artificial sweeteners from your food
  • Eating more beans, pulses, and green leafy vegetables

Changes in dietary habits have a remarkable positive impact on leaky gut syndrome. But still, maintaining an appropriate amount of fiber, minerals, and proteins, especially L-glutamine, is crucial for effective results.

For maintaining relevant nutritional factors, it is good to assist health with supplements. The best supplements for leaky gut contain additional beneficial ingredients such as collagen and L-glutamine. It also contains macro and micronutrients to fulfill the requirements for improving general health conditions.

Read: 11 Best Supplements for Focus and Concentration

There are many available supplements in the market or online. You can also get it online from leaky gut supplements on amazon.

How To Choose The Right Supplement?

Leaky gut is a syndrome; it is a collection of different signs and symptoms that represent differently. Other conditions require different nutritional values for complete relief. For instance, people often ask how much l-glutamine for leaky gut is necessary to protect our intestine?

The answer is the amount that helps relieve the symptoms of the disease.

A good supplement must include:

  • Probiotics
  • Fiber
  • Collagen peptides
  • L-glutamine
  • Zinc
  • Butyrate
  • Curcumin

Each of these ingredients is known to be effective in improving the gut’s health and its maintenance. It also supports the absorption of nutrients from the intestine to the bloodstream.

As the market is full of diversified choices, I must narrow down effective products for your convenience. There are the best supplements for leaky gut in the market for supporting this condition. You can choose the one that clicked your mind to manage leaky gut.

1. Peak BioBoost

best supplements for leaky gut, peak bioboost bottle

Peak BioBoost is not a traditional supplement for treating leaky gut. It mainly focuses on providing daily nutrition requirements and fiber for improving the gut’s health. It is a unique and advanced formula that caught the doctor’s attention.

Doctors and nutritionists to believe that it will help relieve the acute symptoms and provide aid in the long run. With constant use, a patient may become free of the leaky gut syndrome.

Our gut contains some beneficial bacteria that support the breakdown of nutrients and helps them to mix into our bloodstream. If these bacteria die due to any reason, our gut has to face the consequences.

Peak BioBoost solely contains these beneficial bacteria without any additional ingredients. You can consume this supplement along with your tea or coffee. It is proven to reduce inflammation and regularize bowel movements. It is a very effective supplement that shows results after the first use. Hence, it is one of the best supplements for leaky gut.


  • No other ingredients
  • Contains pure culture of probiotics


  • May lack additional benefits from added ingredients

2. Gut Assist – SIBO from Doctor Danielle

best supplements for leaky gut, Gut Assist Bottle

GutAssist aids the restoration of the body’s protective membranes along the GI tract. It does so by providing nutrients like L-Glutamine to help these membranes thrive and recover. Poor gut health can also lead to mood swings, depression, and other imbalances that impact our quality of life.

Maintaining a healthy gut flora and a balanced gut environment is critical for digestive health and gut integrity. The gut wall stores many cells that make up the immune system inside your body.

A healthy gut lining aids nutrient distribution, and a well-balanced digestive tract is necessary for good nutrient delivery. Bloating, IBS, Constipation, diarrhea, cramps, and gas are all symptoms of an unbalanced stomach.

A malfunctioning stomach can also throw off our body’s balance and harmony. It results in a foul mood, despair, anxiety, or tension. Arabinogalactan is a polysaccharide that provides GutAssist with fermentable fiber as well as immunostimulatory effects.

It also promotes the growth of gut bacteria, helps in the creation of short-chain fatty acids. The formula helps to lower ammonia synthesis and absorption. It is the best collagen supplement and certainly, one of the best supplements for leaky gut.


  • Great for Bloating & Gas
  • No side effects as it contains only natural ingredients.
  • Supports immune system


  • A little bit expensive as compared to competitors
  • Sometimes uncomfortable gastrointestinal symptoms.

3. Amen Leaky Gut Supplement

best supplements for leaky gut, amen leaky gut + supplement bottle

Amen Leaky Gut Plus is a digestive supplement containing amino acid L glutamine, zinc, organic turmeric,  marshmallow root, licorice root, and a probiotic blend in a convenient capsule format. The Leaky Gut supplement solution also includes 10 billion CFU of shelf-stable probiotics from plants and soil and four different probiotic strains.

Their probiotics have a long shelf life. L-Glutamine is included in this dietary supplement. Glutamine is an essential amino acid that affects the mucosal cells and digestive tract. These cells are required for the intestine lining.

Glutathione, one of the body’s essential antioxidants, is connected to glutamine. The Amen Leaky Gut supplement also includes a concentrated licorice extract that has been deglycyrrhizinized. The root of licorice is linked to digestive health, motility, and regularity. Due to its unique composition, it is included in this best supplement for leaky gut review.

Amen Leaky Gut is Third Party Tested and produced in the United States. According to a report, it uses non-GMO ingredients in a GMP-certified facility. Consequently, you can consume it at any time of day, with or without meals. You can also break open the capsules and mix the powder into your food or beverage easily.


  • Help in weight loss in a healthy manner
  • Best for treating acne, eczema
  • Budget-friendly


  • With 8 ounces of water, you can take only three capsules daily
  • Before taking, see your primary healthcare physician if you are allergic.

4. Intestinal Fortitude GLR-6 – Leaky Gut Repair Supplement

best supplements for leaky gut, Inestinal Fortitude GLR 6 Supplement bottle

GLR-6 provides a natural means of soothing gastrointestinal tract irritation and ulceration, as well as the fuel it needs to repair itself. Users can improve their gut health and have a better experience. Less bloating, fewer trips to the restroom, less fear of eating, less acid reflux, less diarrhea, and firmer stools are just a few of the benefits.

This maximum strength formula contains 2-6X MORE active ingredients. These ingredients have been scientifically proven to help you feel better, making it the best gut lining repair supplement available.

Six of nature’s most protective compounds are collaborating to repair your mucosal lining. It specifically provides your body with the building blocks required to tighten gastrointestinal junctions.

Our appendages are made in a GMP-certified facility in the United States. They are free of wheat,  gluten, soy, dairy, nuts, GMOs, fish, eggs, preservatives, artificial colors,  and animal derivatives.


  • Helps you with Ulcerative Colitis
  • You can  enjoy food again
  • Cost-effective


  • Only available in Marshmallow, Licorice flavor
  • New  users feel a little uncomfortable

5. All-in-One Gut Health w/Premium Probiotics

best supplements for leaky gut, all in one gut health bottle

Three-in-One digestive supplement gut health is an all-in-one daily gut health supplement. It contains probiotics, digestion-boosting herbs, organic prebiotics, and adaptogens. Our gut hold product is available in a capsule-style that is simple and handy to use.

Their entire gut solution contains 10 billion colony-forming units (CFU) of clinically validated probiotics from nine different strains. All of them are effective to help promote healthy bacteria in the gut. To help keep your heart active and stimulated, this gut health supplement includes an organic prebiotic blend of chicory root and agave.

With turmeric root, ginger root, fenugreek seed, marshmallow powder, and licorice powder, the herbal and adaptogenic combination is an essential part of our probiotic supplement. They promote digestion, relieve stomach pain and reduce inflammation. Nuveen’s goods are created in a GMP-certified facility using non-GMO ingredients.

These pills for leaky gut repair are also shelf-stable and do not require refrigeration. You can also return it to the manufacturer for a refund if you are not completely satisfied with your purchase.


  • Reduces inflammation
  • No adverse effects.
  • Easy to use


  • Only available in capsule form.
  • Costly as compared to other relevant products.

6. Dr. Amy Myers Leaky Gut Revive Powder for Leaky Gut Repair

best supplements for leaky gut, Leaky Gut Revive bottle

Bloating, gas, indigestion, constipation, and even IBS will begin to fade as your gut lining is healed. You’ll sense improvement and have more energy to make the most of your days. Aloe extract aids in the restoration of your gut’s usual mucosal coating.

Licorice extract soothes the intestinal lining and stomach. Good health begins in the heart and stomach. Practically, everyone has a leaky gut due to today’s polluted environments and the ongoing battle with harmful diets. LEAKY GUT REVIVE calms your stomach and promotes the healing of your gut lining. In addition, marshmallow root and slippery elm support gut healing and mucous covering health.

Normal digestive health will return once your gut lining has been healed. It means you’ll have fewer bad cravings and be more interested in eating more substantial foods. Sugar reduction will naturally result in a less irritating stomach and improved digestive function.


  • Effectively heals the intestinal lining
  • No harmful desires after consuming it
  • Easy to digest
  • Long-term impact


  • It is Unflavored
  • Only available in powder form
  • A bit costly as  compared to other relevant products

7. Leaky Gut Defense – Pharmaceutical Grade

best supplements for leaky gut, Leaky Gut Defense supplement bottle

Monk Fruit has been added to sweeten it for additional physical condition benefits. It is available in a powdered form that is simple to mix. This composition is designed to aid healing, necessitating careful ingredient selection: Ingredients are non-GMO and free of China. It is one of the best supplements for leaky gut treatment. They are produced in a GMP-certified facility in the United States for guaranteed quality and potency.

Food allergies, BS or sensitivities, stomach pain, malabsorption, weight issues, digestive disorders, bowel issues, gas and bloating, and many others are symptoms of dysbiosis (leaky gut syndrome).

These Supplements aren’t designed to be a “fast fix”; benefits may take several months to appear, so be patient. When mending your stomach, detox symptoms are common in the first few days or weeks. This implies the product is working!

Do not be frightened if you encounter detox symptoms; reduce your dose to 1/4th of a scoop (or even less) and gradually increase. To assist flush the toxins out, make sure you drink enough water throughout the day.


  • It reduces dehydration.
  • Mineral deficiency issues are resolved
  • Has  detoxification properties


  • Costly
  • Available in powder form only

8. 1MD GutMD – L-Glutamine and Prebiotic for Gut Integrity

best supplements for leaky gut, 1MD GutMD Supplement bottle

GutMD protects your gut against environmental hazards while enabling the nutrients you need to flow through. Thanks to four clinically-tested substances that strengthen the integrity of your intestinal lining. Its composition makes it one of the best supplements for leaky gut support and treatment.

Your gut houses a large amount of your immune system and general health support. So, increasing digestive health can help your immune system cope better with everyday stress. This immune system support aids in the reduction of a variety of symptoms.

Take steps to safeguard your digestive system with substances that can help reinstate bacterial equilibrium. Such substances also strengthen the gut’s usual defenses against toxins and environmental stressors. Guittard, made from licorice root, helps maintain bacterial balance in the stomach, promoting greater motility, regularity, and nutrient absorption.

CARE4U HMO is a gut protector that nourishes the excellent quality microorganisms in your gut. Further, it also assists the body in keeping harmful bacteria levels within the normal range. It does so for a well-balanced, strong intestinal lining.


  • Improves the integrity of the gut lining
  • Has four highly potent, clinically studied ingredients
  • Also boosts the immune system


  • When compared to competitors, it is a little more expensive
  • It is only available in capsule form.

9. Leaky Gut Repair Powder

best supplements for leaky gut, leaky gut repair supplement bottle

For years, progressive physicians have recognized Leaky Gut Syndrome, also known as intestinal permeability, as a significant health risk. “PLAIN UNFLAVORED” and “MINT CHOCOLATE” are two flavors available. Supports repairing a damaged gut lining (Leaky Gut) caused by chemicals and drugs in the environment. At the same time, they are boosting the natural formation of mucilage. It creates a temporary intestinal barrier. Naturopathic physicians prefer it.

Digestive connective tissue is strengthened while diarrhea, constipation, and GI pain are relieved. Our product is US GMP Certified, Gluten, NSF Certified Sugar, Soy,  and GMO-Free. Shellfish and Sulfur are present. While rebalancing GI flora throughout the gut lining repair period, probable initial constipation followed by regularity has been recorded.

Unless they have a sulfur or shellfish allergy, this is usually a brief period. Here we encourage consumers to stay on the product to see improvements. If you have stomach problems, such as heartburn, take one scoop before a meal or bed. Certainly, it is one of the best supplements for leaky gut that help reduce acidity and improving general health.


  • Powder has excellent taste, and it is easy to swallow
  • Boost energy  level


  • Provide temporary intestinal barriers
  • Unflavoured
  • Only available in powder form

10. KaraMD Vital Restore

10. KaraMD Vital Restore, KaraMD Vital Restore Supplement Bottle

The Vital Restore supplement promotes a healthy and balanced gut microbiome for a complete solution to gut health. It helps attain better brain health and immune system maintenance. Meanwhile, it supports natural stomach enzymes, bacteria, and hormones to help heal leaky gut symptoms. It helps restore the lining of your gut.

The supplement thoroughly cleanses the colon and detoxifies it. It also supports weight loss and reduces cravings by optimizing digestive functions. To clarify, it does so by flushing away hazardous substances from your body every day.

Vital Restore also helps enhance cognitive capacity, attention, and vitality. Glutamine is a necessary component of proteins that support the health of critical organs, the intestine, and the immune system. Its composition makes it include among the best supplements for leaky gut.

Berberine, a potent naturally occurring anti-inflammatory substance, is included in this supplement to repair the gut. It subsequently collaborates with your body to maintain healthy microbiota. This natural dietary supplement is backed by science and medical knowledge to help improve stomach and digestive health.

It is a non-GMO, gluten-free, vegan-friendly health supplement manufactured in the United States using high-quality, dependable ingredients. Because we are genuinely concerned about customer understanding, your purchase of KaraMD Vital Restore leaky gut repair and an unconditional 90-day return guarantee fully secures natural gut health complements.


  • Refund policy
  • Cost-effective
  • No side effects


  • No flavor available
  • Only capsule forms are available


A leaky gut syndrome is a severe health condition. It shows various signs and symptoms and also affects your gut health. To sum up, it can be managed by using the correct supplement that contains ingredients to support gut health. Above mentioned ingredients are included to help you fix your purchase online without any hustle. Go and buy your favorite supplement and let us know your feedback!

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